Genel Cerrahi Uzman\u0131 Opr. Dr. Nurullah Burak Korkmaz, s\u0131cak kemoterapi y\u00f6ntemi ile kanserli h\u00fccrelerin normal h\u00fccreler kadar \u0131s\u0131ya dayanamad\u0131\u011f\u0131 ve \u0131s\u0131t\u0131lm\u0131\u015f ila\u00e7lar\u0131n do\u011frudan kar\u0131n t\u00fcm\u00f6rlerine verilmesi sonucu ile t\u00fcm\u00f6ral h\u00fccreleri daha iyi yok etti\u011fini s\u00f6yledi.<\/p>\n
Medicana Samsun Hastanesi Genel Cerrahi Uzman\u0131 Opr. Dr. Nurullah Burak Korkmaz, s\u0131cak kemoterapi (HIPEC) konusunda bilgi verdi. HIPEC\u2019in kanserin kar\u0131n b\u00f6lgesinde ileri evrede yay\u0131ld\u0131\u011f\u0131 ancak kar\u0131n d\u0131\u015f\u0131na yay\u0131lmad\u0131\u011f\u0131 ki\u015filer i\u00e7in bir tedavi se\u00e7ene\u011fi oldu\u011funu belirten Korkmaz, \u201cCerrahi i\u015flem sonras\u0131nda do\u011frudan karn\u0131n i\u00e7ine g\u00f6nderilen olduk\u00e7a konsantre bir s\u0131cak kemoterapi tedavisidir. V\u00fccudu dola\u015fan sistemik kemoterapi verilmesinin aksine olduk\u00e7a konsantre s\u0131v\u0131n\u0131n direk kanser h\u00fccrelerine uygulanmas\u0131 i\u015flemidir. S\u0131cak kemoterapi tedavisinde sol\u00fcsyonun \u0131s\u0131t\u0131lmas\u0131 kemoterapi ila\u00e7lar\u0131n\u0131n t\u00fcm\u00f6rler taraf\u0131ndan emilimi artt\u0131rabilir. Cerrahi i\u015flem sonras\u0131 kar\u0131nda kalan mikroskobik kanser h\u00fccrelerini yok edebilir. S\u0131cak kemoterapi kanserli h\u00fccrelerin normal h\u00fccreler kadar \u0131s\u0131ya dayanamad\u0131\u011f\u0131 ve \u0131s\u0131t\u0131lm\u0131\u015f ila\u00e7lar\u0131n do\u011frudan kar\u0131n t\u00fcm\u00f6rlerine verilmesi sonucu ile t\u00fcm\u00f6ral h\u00fccreleri daha iyi yok etti\u011fi g\u00f6z \u00f6n\u00fcne al\u0131narak uygulanan bir y\u00f6ntemdir\u201d dedi.<\/p>\n
Hangi kanser t\u00fcrlerinde uygulan\u0131r?<\/p>\n
HIPEC\u2019in hangi kanser t\u00fcrlerinde uygulanabilece\u011fi hakk\u0131nda bilgi veren Korkmaz, \u201cYumu\u015fak doku sarkomlar\u0131, over kanseri, mide kanseri, kolon kanseri, apendisk kanseri, wilm t\u00fcm\u00f6rleri, b\u00f6brek bezi kanserleri, dermotolojik k\u00fc\u00e7\u00fck h\u00fccreli t\u00fcm\u00f6rler, kar\u0131n bo\u015flu\u011fundaki di\u011fer kanserlerin tedavisi i\u00e7in uygulan\u0131r. Bu i\u015flemdeki ama\u00e7 ya\u015fam kalitesini ve ya\u015fam s\u00fcresini uzatmak i\u00e7in kullan\u0131lan kombine i\u015flemlerdir\u201d diye konu\u015ftu.<\/p>\n
HIPEC nas\u0131l uygulan\u0131r?<\/p>\n
Hastan\u0131n s\u0131cak kemoterapi tedavisi olmadan \u00f6nce kar\u0131n i\u00e7indeki g\u00f6r\u00fcn\u00fcr t\u00fcm\u00f6rlerin \u00e7\u0131kar\u0131lmas\u0131 i\u00e7in sitoreduktif cerrahi uyguland\u0131\u011f\u0131n\u0131 kaydeden Korkmaz, \u201cSitoreduktif cerrahi yard\u0131m\u0131yla \u00e7e\u015fitli cerrahi teknikler kullan\u0131larak ger\u00e7ekle\u015ftirilir. \u0130nce ba\u011f\u0131rsak, pankreas ve yumurtal\u0131klar gibi metaztatik hastal\u0131klara sahip organlar \u00e7\u0131kar\u0131l\u0131r. Ge\u00e7mi\u015fte kolon kanseri i\u00e7in zaten bir ba\u011f\u0131rsaktan par\u00e7a alma veya t\u00fcm\u00f6r\u00fc doku \u00e7\u0131karma i\u015flemi yap\u0131ld\u0131 ise hipekten maksimum etki sa\u011flamak i\u00e7in sitoreduktif ameliyat\u0131na ihtiya\u00e7 vard\u0131r. M\u00fcmk\u00fcn oldu\u011funca \u00e7ok say\u0131da t\u00fcm\u00f6r \u00e7\u0131kard\u0131ktan sonra hastaya genel anestezi alt\u0131nda iken \u00e7\u0131kard\u0131ktan sonra HIPEC i\u015flemi ba\u015flar. Hipertermi s\u0131cak anlam\u0131na gelmektedir. S\u0131cakl\u0131k kaynama noktas\u0131na de\u011fil ancak v\u00fccut s\u0131cakl\u0131\u011f\u0131ndan daha s\u0131cakt\u0131r. Kemoterapi ila\u00e7lar\u0131n\u0131n \u0131s\u0131t\u0131larak v\u00fccuda verilmesi ile ilac\u0131n potansiyel etkisi artmaktad\u0131r. B\u00f6ylece \u0131s\u0131t\u0131lan sterilize edilmi\u015f kemoterapi sol\u00fcsyonu kanser h\u00fccrelerine n\u00fcfuz ederek kar\u0131n i\u00e7ine g\u00f6nderilir. 41-42 derece aras\u0131nda banyo s\u0131cakl\u0131\u011f\u0131ndaki sol\u00fcsyon yakla\u015f\u0131k bir bu\u00e7uk saat boyunca kar\u0131n i\u00e7ine yay\u0131l\u0131r. Sonras\u0131nda sol\u00fcsyon kar\u0131ndan bo\u015falt\u0131l\u0131r ve kesi kapat\u0131l\u0131r\u201d \u015feklinde konu\u015ftu.<\/p>\n
Avantajlar\u0131<\/p>\n
HIPEC\u2019in avantajlar\u0131 hakk\u0131nda da bilgi veren Korkmaz, \u201cStandart kemoterapiden daha etkili daha g\u00fcvenli ve y\u00fcksek bir kemoterapi konsantrasyonu sa\u011flanmas\u0131na yard\u0131mc\u0131 olur. Y\u00fcksek doz kemoterapiye imkan verir. V\u00fccudun geri kalan\u0131n\u0131n kemoterapiye maruz kalmas\u0131n\u0131 en az seviyeye indirir. Kemoterapi ajan\u0131 s\u0131cak etkisi ile t\u00fcm\u00f6r h\u00fccrelerinin yok edilmesine katk\u0131 sa\u011flar\u201d ifadelerini kulland\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":"
GENEL CERRAH\u0130 UZMANI OPR. DR. NURULLAH BURAK KORKMAZ, SICAK KEMOTERAP\u0130 Y\u00d6NTEM\u0130 \u0130LE KANSERL\u0130 H\u00dcCRELER\u0130N NORMAL H\u00dcCRELER KADAR ISIYA DAYANAMADI\u011eI VE ISITILMI\u015e \u0130LA\u00c7LARIN DO\u011eRUDAN KARIN T\u00dcM\u00d6RLER\u0130NE VER\u0130LMES\u0130 SONUCU \u0130LE T\u00dcM\u00d6RAL H\u00dcCRELER\u0130 DAHA \u0130Y\u0130 YOK ETT\u0130\u011e\u0130N\u0130 S\u00d6YLED\u0130.<\/p>\n","protected":false},"author":1,"featured_media":166483,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1018,2716,15223,192,1552,13131,256,39722,664],"class_list":["post-166482","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-daha","tag-ediliyor","tag-hucreler","tag-ile","tag-iyi","tag-kemoterapi","tag-sicak","tag-tumoral","tag-yok"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.tvturk.com\/wp-content\/uploads\/2019\/06\/sicak-kemoterapi-ile-tumoral-hucreler-daha-iyi-yok-ediliyor_807e1f5.jpg?fit=790%2C1000","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paKIfm-Hjc","_links":{"self":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/166482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/comments?post=166482"}],"version-history":[{"count":0,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/166482\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media\/166483"}],"wp:attachment":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media?parent=166482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/categories?post=166482"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/tags?post=166482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}