Ba\u015fkanl\u0131\u011f\u0131n\u0131 Prof. Dr. Adil Mardino\u011flu ve Genel Sekreterli\u011fini Prof. Dr. Hasan T\u00fcrkez\u2019in yapt\u0131\u011f\u0131 T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) taraf\u0131ndan yeni y\u00f6netim d\u00f6neminde ba\u015flat\u0131lan yenilik\u00e7i ve \u00fcr\u00fcn odakl\u0131 proje \u00e7a\u011fr\u0131lar\u0131na bir yenisi daha eklendi.<\/p>\n
Literat\u00fcrde yer alan biyolojik veri setlerinin hesaplamal\u0131 analizleri sonucunda, hastal\u0131klar\u0131n tan\u0131, takip ve tedavisine y\u00f6nelik yenilik\u00e7i yakla\u015f\u0131mlar\u0131n geli\u015ftirilmesinin ama\u00e7land\u0131\u011f\u0131 bu \u00e7a\u011fr\u0131 kapsam\u0131ndaki projelerin ba\u015fvurusu 15 Ekim\u2019de sona erecek.<\/p>\n
T\u00dcSEB taraf\u0131ndan yap\u0131lan yaz\u0131l\u0131 a\u00e7\u0131klamada, \u201cBireysel t\u0131p, her bireyin kendisine \u00f6zg\u00fc \u00f6zelliklerine dayanarak hastal\u0131klar\u0131n \u00f6nlenmesi, te\u015fhisi ve tedavisi i\u00e7in optimize edilmi\u015f bir stratejidir. Bu yakla\u015f\u0131mda birey, sa\u011fl\u0131k hizmetinin tam merkezine yerle\u015ftirilmekte, tedavinin ve\/veya hastal\u0131\u011fa yatk\u0131nl\u0131\u011f\u0131n en iyi \u015fekilde y\u00f6netilmesi hedeflenmektedir. Bireysel t\u0131p uygulamalar\u0131na y\u00f6nelim, \u201cherkese uyan ortak \u00e7\u00f6z\u00fcm\u201d paradigmas\u0131n\u0131n de\u011fi\u015fimini temsil etmektedir. Ba\u015fta omik teknolojileri olmak \u00fczere tan\u0131sal testler, t\u0131bbi g\u00f6r\u00fcnt\u00fcleme sistemleri, biyolojik izleme y\u00f6ntemleri, molek\u00fcler bilgi birikimi, ya\u015fam tarz\u0131 verileri, ko\u015fullar\u0131n ger\u00e7ek zamanl\u0131 izlenmesi ve bilgi teknolojisi gibi alanlardaki son geli\u015fmeler bireysel t\u0131p yakla\u015f\u0131m\u0131n\u0131 d\u00f6n\u00fc\u015f\u00fcmsel k\u0131lm\u0131\u015f ve klini\u011fe uygulama s\u00fcrecini kolay, pratik ve s\u00fcrd\u00fcr\u00fclebilir seviyeye ta\u015f\u0131m\u0131\u015ft\u0131r\u201d denildi.<\/p>\n
T\u00dcSEB\u2019in \u00f6ncelikli hedeflerinden birinin bireysel t\u0131bb\u0131 sa\u011fl\u0131k sisteminde uygulamaya koymak i\u00e7in gerekli ad\u0131mlar\u0131 atmak, \u00f6nleyici ve \u00f6ng\u00f6r\u00fcc\u00fc sa\u011fl\u0131k modellerinin uygulanabilir olmas\u0131n\u0131 sa\u011flamak oldu\u011fu belirtilen a\u00e7\u0131klamada, \u201cHedeflenmi\u015f tan\u0131\/takip\/tedavi stratejilerinin geli\u015ftirilmesi, bireylerin ya\u015fam s\u00fcresini ve klinik uygulamalar\u0131n kalitesini artt\u0131rman\u0131n yan\u0131 s\u0131ra erken te\u015fhis, \u00f6nleme, risk de\u011ferlendirmesi ve bak\u0131m hizmeti gibi s\u00fcre\u00e7lerde iyile\u015ftirmeler sa\u011flayaca\u011f\u0131ndan, sa\u011fl\u0131k sistemlerinde finansal kaynaklar\u0131n daha verimli kullan\u0131lmas\u0131na imkan verecektir. Farkl\u0131 biyolojik seviyelerde h\u00fccre i\u00e7i molek\u00fcllerin belirlenmesine y\u00f6nelik geli\u015ftirilen h\u0131zl\u0131 tarama y\u00f6ntemleri sayesinde, ayn\u0131 anda y\u00fczlerce biyomolek\u00fcl\u00fcn \u00f6l\u00e7\u00fclebilmesi m\u00fcmk\u00fcn hale gelmi\u015ftir. Bu sayede, \u00e7ok say\u0131da fenotip i\u00e7in genom, transkriptom, proteom, metabolom vb. d\u00fczeylerde veriler elde edilmi\u015f ve ilgili veri setleri \u00e7e\u015fitli veritabanlar\u0131nda toplanarak ara\u015ft\u0131rmac\u0131lar\u0131n \u00fccretsiz eri\u015fimine sunulmu\u015ftur. \u00d6rne\u011fin, a\u011f\u0131rl\u0131kl\u0131 olarak transkriptom verisi sa\u011flayan NCBI veritaban\u0131 Gene Expression Omnibus\u2019ta, farkl\u0131 fenotiplerin incelenmesini hedefleyen 110000\u2019in \u00fczerinde veri seti yer almaktad\u0131r. \u00d6te yandan, omik verileri olarak da bilinen bu verileri belli bir hastal\u0131\u011fa \u00f6zg\u00fc \u015fekilde b\u00fcnyesinde toplayan veritabanlar\u0131 da bulunmaktad\u0131r. \u00d6rne\u011fin, TCGA veritaban\u0131 33 farkl\u0131 kanser t\u00fcr\u00fcne ait binlerce genom ve transkriptom verisini b\u00fcnyesinde bar\u0131nd\u0131rmaktad\u0131r” denildi.<\/p>\n
A\u00e7\u0131klamada \u015funlar kaydedildi:<\/p>\n
“Literat\u00fcrde mevcut olan veri setlerinin hesaplamal\u0131 analizi sonucunda aday biyobelirte\u00e7, ila\u00e7 hedefi veya ila\u00e7lar belirlenebilmekte, b\u00f6ylece \u00e7ok daha h\u0131zl\u0131 ve d\u00fc\u015f\u00fck maliyetli olan bu yakla\u015f\u0131m sayesinde hastal\u0131klar\u0131n tan\u0131\/takip\/tedavisine y\u00f6nelik daha ak\u0131lc\u0131 stratejilerinin tasarlanmas\u0131 m\u00fcmk\u00fcn olmaktad\u0131r\u201d denilmektedir.<\/p>\n
Bu \u00e7a\u011fr\u0131 kapsam\u0131nda T\u00dcSEB hastal\u0131klar\u0131n birden \u00e7ok omik veri tipinin molek\u00fcler etkile\u015fim a\u011flar\u0131yla birlikte kullan\u0131larak tan\u0131\/tedavi ve alt grup belirleme odakl\u0131 ara\u015ft\u0131r\u0131lmas\u0131, hastal\u0131klar\u0131n sistem biyolojisi, yapay zeka, makine \u00f6\u011frenmesi, derin \u00f6\u011frenme algoritmalar\u0131 kullan\u0131larak tan\u0131\/tedavi ve alt grup belirleme odakl\u0131 ara\u015ft\u0131r\u0131lmas\u0131, yeni ila\u00e7 hedeflerinin ve bu hedeflere y\u00f6nelik yeni aday ila\u00e7 molek\u00fcllerinin belirlenmesi, mevcut bir ilac\u0131n ba\u015fka bir hastal\u0131\u011f\u0131n tedavisi i\u00e7in kullan\u0131labilirli\u011fini ara\u015ft\u0131ran ila\u00e7 yeniden konumland\u0131rma (repozisyon) \u00e7al\u0131\u015fmalar\u0131, omik veri analizlerinin kullan\u0131ld\u0131\u011f\u0131 hastal\u0131k tan\u0131, takip ve tedavisine y\u00f6nelik aday biyobelirte\u00e7, kit, ila\u00e7 ve a\u015f\u0131 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131, \u00f6nleyici m\u00fcdahaleler i\u00e7in pop\u00fclasyonu s\u0131n\u0131fland\u0131rarak hastal\u0131\u011f\u0131n ba\u015flamas\u0131n\u0131 geciktirebilecek ya da ilerlemesini yava\u015flatmaya y\u00f6nelik \u00e7al\u0131\u015fmalar, hastal\u0131k \u00f6nleme tedavilerinden faydalanabilecek potansiyel hasta pop\u00fclasyonunun tan\u0131mlanmas\u0131na y\u00f6nelik \u00e7al\u0131\u015fmalar, daha etkili ve yenilik\u00e7i tedavi y\u00f6ntemleri geli\u015ftirmeye y\u00f6nelik \u00e7al\u0131\u015fmalara destek verilecektir. Proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fcn\u00fcn \u00fcniversite veya kamu kurum\/kurulu\u015fu personeli olmas\u0131 durumunda en az doktora\/t\u0131pta uzmanl\u0131k derecesine sahip olmas\u0131 (bu ko\u015ful e\u011fitim ve ara\u015ft\u0131rma hastanelerinde g\u00f6rev yapanlar\u0131 da kapsamaktad\u0131r), \u00f6zel kurulu\u015f personeli olmas\u0131 halinde en az 4 y\u0131ll\u0131k lisans mezunu olmas\u0131 gerekmektedir. Proje ba\u015fvurusu ve \u00e7a\u011fr\u0131 ile ilgili detaylara https:\/\/tbys.tuseb.gov.tr\/#\/aktifcagrilistesidispanel linkinden ula\u015f\u0131labilir.”<\/p>\n","protected":false},"excerpt":{"rendered":"
BA\u015eKANLI\u011eINI PROF. DR. AD\u0130L MARD\u0130NO\u011eLU VE GENEL SEKRETERL\u0130\u011e\u0130N\u0130 PROF. DR. HASAN T\u00dcRKEZ\u2019\u0130N YAPTI\u011eI T\u00dcRK\u0130YE SA\u011eLIK ENST\u0130T\u00dcLER\u0130 BA\u015eKANLI\u011eI (T\u00dcSEB) TARAFINDAN YEN\u0130 Y\u00d6NET\u0130M D\u00d6NEM\u0130NDE BA\u015eLATILAN YEN\u0130L\u0130K\u00c7\u0130 VE \u00dcR\u00dcN ODAKLI PROJE \u00c7A\u011eRILARINA B\u0130R YEN\u0130S\u0130 DAHA EKLEND\u0130.<\/p>\n","protected":false},"author":1,"featured_media":199534,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[6991,50166,50165,5140,1456,494,49995],"class_list":["post-199533","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-ar-ge","tag-biyoinformatik","tag-biyolojisi","tag-cagrisi","tag-proje","tag-sistem","tag-tusebden"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.tvturk.com\/wp-content\/uploads\/2019\/09\/tusebden-sistem-biyolojisi-ve-biyoinformatik-ar-ge-proje-cagrisi_433a601.jpg?fit=1000%2C557","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paKIfm-PUh","_links":{"self":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/199533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/comments?post=199533"}],"version-history":[{"count":0,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/199533\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media\/199534"}],"wp:attachment":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media?parent=199533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/categories?post=199533"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/tags?post=199533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}