Sel\u00e7uk \u00dcniversitesi (S\u00dc) bilim adamlar\u0131, T\u00fcrkiye\u2019de ilk yerli do\u011fal kaynakl\u0131 kanser ilac\u0131 aday\u0131 geli\u015ftiriyor.<\/p>\n
Sel\u00e7uk \u00dcniversitesi Fen Fak\u00fcltesi Kimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Prof. Dr. Mustafa Y\u0131lmaz, Biyokimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Serdar Karakurt, Yunanistan ve \u0130talya\u2019dan bilim adamlar\u0131n\u0131n da katk\u0131lar\u0131yla T\u00fcrkiye\u2019de ilk yerli do\u011fal kaynakl\u0131 kanser ilac\u0131 aday\u0131 geli\u015ftiriyor. Sel\u00e7uk \u00dcniversitesi Kimya B\u00f6l\u00fcm\u00fc grubunun 4 y\u0131l \u00f6nce Yunanistan\u2019daki bir biyokimya grubu ile ikili uluslararas\u0131 bir proje \u00e7er\u00e7evesinden bu konuyu g\u00fcndemine alarak bir proje ger\u00e7ekle\u015ftirdi\u011fini s\u00f6yleyen Prof. Dr. Y\u0131lmaz, projenin T\u00fcrk taraf\u0131n\u0131 T\u00dcB\u0130TAK\u2019\u0131n destekledi\u011fini belirtti. Canl\u0131 denemelerin \u0130talya\u2019da yap\u0131ld\u0131\u011f\u0131 \u00e7al\u0131\u015fmada T\u00fcrkiye taraf\u0131ndan 3, Yunanistan\u2019dan 9 ve \u0130talya\u2019dan 1 bilim insan\u0131 projede yer ald\u0131.<\/p>\n
T\u00fcrkiye\u2019nin ilk yerli do\u011fal kaynakl\u0131 kanser ilac\u0131yla ilgili bilgi veren Fen Fak\u00fcltesi Kimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Prof. Dr. Mustafa Y\u0131lmaz, gruplar\u0131n\u0131n Sel\u00e7uk \u00dcniversitesi Kimya B\u00f6l\u00fcm\u00fc Ara\u015ft\u0131rma Laboratuvarlar\u0131nda yakla\u015f\u0131k 20 y\u0131ldan beri nanosepetler \u00fczerine \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 s\u00f6yledi. Prof. Dr. Y\u0131lmaz, \u201cNanosepetleri \u00e7ok de\u011fi\u015fik ama\u00e7larda kulland\u0131k. Son y\u0131llarda bu bile\u015fikleri antikanser \u00e7al\u0131\u015fmalarda kullanmaktay\u0131z. Bildi\u011finiz gibi sebze ve meyvenin yap\u0131s\u0131nda flavonoidler bulunmaktad\u0131r. Bu flavonoidler i\u00e7erisinde ise en fazla bulunanlardan bir tanesi de kuersetin olup antikanser \u00f6zelli\u011fe sahiptir ve ticari olarak da elde etmek m\u00fcmk\u00fcnd\u00fcr. Belirlenen dozlarda sa\u011fl\u0131kl\u0131 dokulara \u00e7ok fazla zarar vermezken, kanser dokular\u0131nda ise etkili olmaktad\u0131r. Ancak kuersetinin sudaki \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fcn\u00fcn olduk\u00e7a az olmas\u0131ndan dolay\u0131 \u015fimdiye kadar sa\u011fl\u0131k alan\u0131nda kabul g\u00f6rmemi\u015f, antikanser \u00f6zelli\u011finden yeterince faydalan\u0131lamam\u0131\u015ft\u0131r. Bu duruma \u015f\u00f6yle bir a\u00e7\u0131kl\u0131k getirebilirim; Yap\u0131lan \u00e7al\u0131\u015fmalarda 4 gram a\u011f\u0131rl\u0131\u011f\u0131nda kuersetin g\u00f6n\u00fcll\u00fc sa\u011fl\u0131kl\u0131 insanlara oral yoldan verdirildi\u011finde, bu insanlar\u0131n kan\u0131nda ve idrar\u0131nda kuersetine rastlan\u0131lmam\u0131\u015f olmas\u0131 bu bile\u015fi\u011fin suda \u00e7\u00f6z\u00fcnmedi\u011fini ve emiliminin olduk\u00e7a d\u00fc\u015f\u00fck oldu\u011funu g\u00f6stermektedir. Geli\u015ftirdi\u011fimiz suda \u00e7\u00f6z\u00fcnebilen bu nanosepetlere kuersetin, fizyolojik ortamda y\u00fcklenerek tamamen suda \u00e7\u00f6z\u00fcnebilir duruma getirildi\u201d dedi.<\/p>\n
Kimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Prof. Dr. Y\u0131lmaz \u00e7al\u0131\u015fmalar\u0131nda geldikleri a\u015famay\u0131 anlatt\u0131. Prof. Dr. Y\u0131lmaz, \u201cFaz I \u00e7al\u0131\u015fmalar\u0131n\u0131 tamamlad\u0131k, faz II \u00e7al\u0131\u015fmalar\u0131nda ise fare denemeleri \u0130talya\u2019da \u00f6zel bir laboratuvarda ba\u015far\u0131 ile sonu\u00e7land\u0131. Haz\u0131rlad\u0131\u011f\u0131m\u0131z ila\u00e7 aday\u0131 ajan\u0131n canl\u0131 v\u00fccudunda kolon kanseri h\u00fccrelerini \u00f6nemli oranda inhibe etti\u011fi bulundu. Ta\u015f\u0131y\u0131c\u0131 molek\u00fcl kuarsetini kanser h\u00fccrelerinin pH\u2019s\u0131nda sal\u0131p sa\u011fl\u0131kl\u0131 h\u00fccrelerin pH\u2019s\u0131nda salmamaktad\u0131r. Bu ila\u00e7 aday\u0131n\u0131n di\u011fer kanser ila\u00e7lar\u0131ndan fark\u0131, do\u011fal bir kaynaktan elde edilmesinin yan\u0131nda hedefli ve kontroll\u00fc bir \u015fekilde kanserli h\u00fccreye y\u00f6nelip sal\u0131n\u0131m yapmas\u0131d\u0131r\u201d \u015feklinde konu\u015ftu.<\/p>\n
\u00c7al\u0131\u015fman\u0131n Amerika\u2019da bu konuda yay\u0131nlanan \u00f6nemli bir dergiye (ACS Applied Bio Materials) kapak olarak se\u00e7ilerek bas\u0131ld\u0131\u011f\u0131n\u0131 dile getiren Prof. Dr. Y\u0131lmaz, \u201cBizim \u00e7al\u0131\u015fmalar\u0131m\u0131zda ve her konuda destek olan Sel\u00e7uk \u00dcniversitesi Rekt\u00f6rl\u00fc\u011f\u00fcne, Fen Fak\u00fcltesi Dekanl\u0131\u011f\u0131na, Kimya ve Biyokimya B\u00f6l\u00fcm Ba\u015fkanlar\u0131na ve maddi deste\u011finden dolay\u0131 T\u00dcB\u0130TAK\u2019a ve S\u00dc Bilimsel Ara\u015ft\u0131rma Projeler Koordinat\u00f6rl\u00fc\u011f\u00fcne de te\u015fekk\u00fcr ederiz\u201d ifadelerini kulland\u0131.<\/p>\n
\u201c7 farkl\u0131 insan kanseri \u00fczerinde denedik\u201d<\/p>\n
Geli\u015ftirilen bu ila\u00e7 adaylar\u0131n\u0131n \u00f6nce laboratuvar ortam\u0131nda bir\u00e7ok insan kanser h\u00fccresi \u00fczerinde denemelerinin yap\u0131ld\u0131\u011f\u0131n\u0131 kaydeden Biyokimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Serdar Karakurt ise, \u201cOrganik Kimya grubumuzun sentezlemi\u015f oldu\u011fu bu ila\u00e7 ta\u015f\u0131y\u0131c\u0131 sistemi biz, 7 farkl\u0131 insan kanseri \u00fczerinde denedik. Bu kanser gruplar\u0131 i\u00e7erisinde; kolon, akci\u011fer, karaci\u011fer, prostat, meme, rahim a\u011fz\u0131 ve b\u00f6brek kanser tipleri bulunmakta ve bu tip kanser t\u00fcrleri i\u00e7erisinde en fazla kolon kanseri \u00fczerinde etkili oldu\u011funu g\u00f6rd\u00fck. Daha sonra kolon kanseri h\u00fccreleri i\u00e7erisinde 6 farkl\u0131 karakteristikte insan kolon kanseri h\u00fccreleri ile bu ta\u015f\u0131y\u0131c\u0131 sistemin etkisinin ne derece oldu\u011funu inceledik. Se\u00e7ici olarak metastaz yapm\u0131\u015f kolon kanseri h\u00fccreleri \u00fczerinde y\u00fcksek oranda toksik etki g\u00f6sterdi\u011fini g\u00f6rd\u00fck. Normalde kuersetinin kendisinin kolon kanseri h\u00fccresi \u00fczerine g\u00f6sterdi\u011fi etkiyi ta\u015f\u0131y\u0131c\u0131 sistemle 52 kat art\u0131rd\u0131k. B\u00f6ylece y\u00fczde 90-95 oranlar\u0131nda kolon kanserinin geli\u015fimini h\u00fccre k\u00fclt\u00fcr \u00e7al\u0131\u015fmalar\u0131nda durdurduk ve bunun molek\u00fcler mekanizmas\u0131n\u0131 a\u00e7\u0131klad\u0131k. Daha sonra farelerde kolon kanseri modelleri olu\u015fturuldu. Bu kolon kanseri modellerinde tedavi amac\u0131yla ta\u015f\u0131y\u0131c\u0131 molek\u00fcl\u00fcm\u00fcz ve kuersetin molek\u00fcl\u00fc enjekte edildi ve y\u00fcksek oranda canl\u0131 dokusunda kolon kanserinin geriledi\u011fi g\u00f6zlemlendi\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"
SEL\u00c7UK \u00dcN\u0130VERS\u0130TES\u0130 FEN FAK\u00dcLTES\u0130 K\u0130MYA B\u00d6L\u00dcM\u00dc \u00d6\u011eRET\u0130M \u00dcYES\u0130 PROF. DR. MUSTAFA YILMAZ (SA\u011eDA), B\u0130YOK\u0130MYA B\u00d6L\u00dcM\u00dc \u00d6\u011eRET\u0130M \u00dcYES\u0130 DO\u00c7. DR. SERDAR KARAKURT, YUNAN\u0130STAN VE \u0130TALYA\u2019DAN B\u0130L\u0130M ADAMLARININ DA KATKILARIYLA T\u00dcRK\u0130YE\u2019DE \u0130LK YERL\u0130 DO\u011eAL KAYNAKLI KANSER \u0130LACI ADAYI GEL\u0130\u015eT\u0130R\u0130YOR.<\/p>\n","protected":false},"author":1,"featured_media":216790,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[135,1084,26864,17542,350,40706,4454,382],"class_list":["post-216789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-adayi","tag-dogal","tag-gelistiriyor","tag-ilaci","tag-kanser","tag-kaynakli","tag-selcuk","tag-universitesi"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.tvturk.com\/wp-content\/uploads\/2019\/10\/selcuk-universitesi-dogal-kaynakli-kanser-ilaci-adayi-gelistiriyor_655c3fc.jpg?fit=1000%2C666","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paKIfm-UoB","_links":{"self":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/216789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/comments?post=216789"}],"version-history":[{"count":0,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/216789\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media\/216790"}],"wp:attachment":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media?parent=216789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/categories?post=216789"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/tags?post=216789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}