Do\u00e7. Dr. G\u00fcrb\u00fcz G\u00f6r\u00fcml\u00fc, g\u00fcn\u00fcm\u00fczde kanser h\u00fccresinin genetik haritas\u0131n\u0131n \u00e7\u0131kar\u0131labildi\u011fini, bunun da tedavide ba\u015far\u0131y\u0131 art\u0131rd\u0131\u011f\u0131n\u0131 s\u00f6yledi. G\u00f6r\u00fcml\u00fc, \u201cMolek\u00fcler genetik testler sayesinde de hangi kemoterapi ilac\u0131n\u0131n hangi hastaya daha faydal\u0131 olabilece\u011fi saptanabiliyor, hangi hastan\u0131n hangi hedefe y\u00f6nelik tedaviden fayda g\u00f6rece\u011finin ortaya \u00e7\u0131kar\u0131lmas\u0131 m\u00fcmk\u00fcn olabiliyor\u201d dedi.<\/p>\n
Kent Onkoloji Merkezi Medikal Onkoloji Uzman\u0131 Do\u00e7. Dr. G\u00f6r\u00fcml\u00fc, kanser tedavisindeki \u00f6nemli ve umut verici geli\u015fmelere dikkat \u00e7ekti. Kanserin ki\u015finin kendi sa\u011fl\u0131kl\u0131 h\u00fccrelerinden geli\u015fti\u011fini, o h\u00fccrelerin ki\u015fiye \u00f6zel genetik \u015fifreler ta\u015f\u0131d\u0131\u011f\u0131n\u0131 belirten Do\u00e7. Dr. G\u00f6r\u00fcml\u00fc, \u201cBu sebeple her kanserde t\u00fcr\u00fc ayn\u0131 da olsa tedaviden elde edilen sonu\u00e7lar her ki\u015fi i\u00e7in farkl\u0131 olabilmektedir. Bu durum kanser tedavisinde ki\u015fiye \u00f6zel yakla\u015f\u0131m\u0131n \u00f6nemini ortaya koymaktad\u0131r\u201d diye konu\u015ftu.<\/p>\n
G\u00f6r\u00fcml\u00fc \u015fu bilgileri verdi:<\/p>\n
\u201c\u00c7a\u011f\u0131m\u0131z\u0131n en \u00f6nemli sa\u011fl\u0131k problemlerinin ba\u015f\u0131nda gelen kanser, g\u00fcn\u00fcm\u00fczde ki\u015fiye \u00f6zel tedavi ile korkulacak bir hastal\u0131k olmaktan giderek uzakla\u015fmaktad\u0131r. Tedaviye y\u00f6nelik her ge\u00e7en g\u00fcn yeni geli\u015fmeler ve \u00f6zel tedaviler \u00f6n plana \u00e7\u0131kmaktad\u0131r. Son y\u0131llarda \u2018yeni nesil dizileme\u2019 (NGS -Next Generation Sequencing) olarak adland\u0131r\u0131lan y\u00f6ntemle kanser h\u00fccresinin genetik haritas\u0131n\u0131n \u00e7\u0131kar\u0131lmas\u0131 m\u00fcmk\u00fcn olabilmektedir. Bu \u00f6zel molek\u00fcler genetik inceleme y\u00f6ntemi kanserli dokudan al\u0131nan bir par\u00e7a (biyopsi) veya bazen basit bir kan \u00f6rne\u011fi ile yap\u0131labilmektedir. NGS incelemesi sonucunda elde edilen kanserin genetik haritas\u0131nda \u00e7e\u015fitli molek\u00fcler genetik bozukluklar, mutasyonlar, kanser h\u00fccrelerinin \u00e7o\u011falma yollar\u0131 tespit edilebilmektedir. Son y\u0131llarda bu \u00e7o\u011falma yollar\u0131n\u0131 keserek t\u00fcm\u00f6r h\u00fccrelerinin \u00f6l\u00fcm\u00fcne yol a\u00e7an son derece etkili \u2018ak\u0131ll\u0131 ila\u00e7\u2019 ya da \u2018hedefe y\u00f6nelik ila\u00e7\u2019 olarak da adland\u0131r\u0131lan tedavilerin ke\u015ffedilmesi kanser tedavisinde yeni bir \u00e7\u0131\u011f\u0131r a\u00e7m\u0131\u015ft\u0131r.\u201d<\/p>\n
Test i\u00e7in kan ya da biyopsi \u00f6rne\u011fi yetiyor<\/p>\n
Amerika\u2019n\u0131n en \u00f6nemli kanser merkezlerinden Houston Methodist Hospital i\u015fbirli\u011fi ile hizmet veren Kent Onkoloji Merkezi\u2019nde isteyen hastalar\u0131n kendileri arac\u0131l\u0131\u011f\u0131yla bu testleri yapt\u0131rabildi\u011fini kaydeden Do\u00e7. Dr. G\u00f6r\u00fcml\u00fc, s\u00f6zlerini \u015f\u00f6yle s\u00fcrd\u00fcrd\u00fc:<\/p>\n
\u201cMolek\u00fcler genetik testler i\u00e7in Amerika ve Avrupa\u2019daki baz\u0131 merkezlerden hizmet al\u0131yoruz. \u0130steyen hastalar\u0131n kan ya da biyopsi \u00f6rneklerini bu laboratuvarlara g\u00f6nderip ald\u0131\u011f\u0131m\u0131z sonu\u00e7lara g\u00f6re tedavilerini planl\u0131yoruz. Bu genetik testler ba\u015fta akci\u011fer, meme, kal\u0131n barsak, b\u00f6brek ve melanom ad\u0131 verilen cilt kanserlerinin \u00f6zel bir t\u00fcr\u00fcnde olmak \u00fczere hemen hemen t\u00fcm kanser t\u00fcrlerinde yava\u015f yava\u015f prati\u011fimize girdi. Bu sayede hastalar\u0131m\u0131z\u0131n uygun ak\u0131ll\u0131 ila\u00e7lar\u0131 kullan\u0131labilmesi m\u00fcmk\u00fcn hale gelirken, tedavi ba\u015far\u0131lar\u0131nda belirgin art\u0131\u015flar sa\u011fland\u0131. Yine bu molek\u00fcler genetik testler ile hangi kemoterapi ilac\u0131n\u0131n hangi hastaya daha faydal\u0131 olabilece\u011fi saptanabiliyor, hangi hastan\u0131n hangi hedefe y\u00f6nelik tedaviden fayda g\u00f6rece\u011finin ortaya \u00e7\u0131kar\u0131lmas\u0131 m\u00fcmk\u00fcn olabiliyor. Bu genetik haritalama y\u00f6ntemi ile ayn\u0131 zamanda imm\u00fcnoterapi tedavilerinin de ne derece etkili olabilece\u011fi tespit edilebiliyor.\u201d<\/p>\n
Gen bozukluklar\u0131 da saptan\u0131yor<\/p>\n
Do\u00e7. Dr. G\u00f6r\u00fcml\u00fc, bu hassas molek\u00fcler gen analiz y\u00f6ntemleri ile t\u00fcm\u00f6r\u00fcn kaynakland\u0131\u011f\u0131 organa bak\u0131lmaks\u0131z\u0131n kanserle\u015fme s\u00fcrecinde ana rol alan baz\u0131 \u00f6zel gen bozukluklar\u0131n\u0131n da saptanabildi\u011fini s\u00f6yledi. G\u00f6r\u00fcml\u00fc, \u201cBu spesifik genetik bozukluklar\u0131n tespiti durumunda hemen her kanser t\u00fcr\u00fcnde, tedaviye diren\u00e7li ilerlemi\u015f hastal\u0131\u011f\u0131 olan kanser hastalar\u0131nda dahi, ak\u0131ll\u0131 ila\u00e7 ya da immunoterapi tedavileri ile \u00f6nemli ba\u015far\u0131lar elde edilebilmektedir. Sonu\u00e7 olarak ki\u015fiye \u00f6zel onkolojik tedavi yakla\u015f\u0131mlar\u0131 h\u0131zla geli\u015fim g\u00f6stermekte ve beraberinde kanserin seyrinin h\u0131zla de\u011fi\u015fmesine olanak sa\u011flamaktad\u0131r\u201d dedi.<\/p>\n","protected":false},"excerpt":{"rendered":"
DO\u00c7. DR. G\u00dcRB\u00dcZ G\u00d6R\u00dcML\u00dc G\u00dcN\u00dcM\u00dcZDE KANSER H\u00dcCRES\u0130N\u0130N GENET\u0130K HAR\u0130TASININ \u00c7IKARILAB\u0130LD\u0130\u011e\u0130N\u0130, BUNUN DA TEDAV\u0130DE BA\u015eARIYI ARTIRDI\u011eINI S\u00d6YLED\u0130.<\/p>\n","protected":false},"author":1,"featured_media":220518,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1],"tags":[15098,350,12099,43934,7313],"class_list":["post-220517","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-genetik","tag-kanser","tag-rehber","tag-tedavisine","tag-testler"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.tvturk.com\/wp-content\/uploads\/2019\/10\/genetik-testler-kanser-tedavisine-rehber_0a4780f.jpg?fit=1000%2C636","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paKIfm-VmJ","_links":{"self":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/220517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/comments?post=220517"}],"version-history":[{"count":0,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/220517\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media\/220518"}],"wp:attachment":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media?parent=220517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/categories?post=220517"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/tags?post=220517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}