\u0130la\u00e7 tedavisinin hastalar\u0131n genetik yap\u0131s\u0131na g\u00f6re etkilerini saptayan farmakogenetik \u00e7al\u0131\u015fmalar\u0131n\u0131n \u00f6nemi g\u00fcn ge\u00e7tik\u00e7e artt\u0131\u011f\u0131 belirtiliyor. Farmakogenetik testler; hangi hastan\u0131n, hangi ilac\u0131, hangi dozda kullanmas\u0131 gerekti\u011fini s\u00f6yl\u00fcyor. Bunun sonucunda Maltepe \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Farmakoloji Anabilim Dal\u0131\u2019na ba\u011fl\u0131 olarak T\u0131p Fak\u00fcltesi Hastanesinde a\u00e7\u0131lan Farmakogenetik Poliklini\u011fi, ila\u00e7lar\u0131n etkilerini belirleyen Farmakogenetik testleri uygulamaya ba\u015flad\u0131\u011f\u0131n\u0131 a\u00e7\u0131klad\u0131.<\/p>\n
Maltepe \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Farmakoloji Anabilim Dal\u0131\u2019na ba\u011fl\u0131 olarak T\u0131p Fak\u00fcltesi Hastanesinde a\u00e7\u0131lan Farmakogenetik Poliklini\u011fi, ila\u00e7lar\u0131n etkilerini belirleyen farmakogenetik testleri uygulamaya ba\u015flad\u0131. Hastalar\u0131n hangi ilaca nas\u0131l tepki verece\u011fini saptayan klinikte, yanl\u0131\u015f ila\u00e7 kullan\u0131m\u0131n\u0131n da \u00f6n\u00fcne ge\u00e7ilecek. Ama\u00e7, hastan\u0131n geneti\u011fine uygun, do\u011fru ve yeterli dozda verilen ila\u00e7larla tedavideki ba\u015far\u0131 oranlar\u0131n\u0131 y\u00fckseltmek.<\/p>\n
Maltepe \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Farmakoloji Anabilim Dal\u0131 Ba\u015fkan\u0131 Prof. Dr. Esra Sa\u011flam, \u00f6n\u00fcm\u00fczdeki y\u0131llarda rutin tedavi s\u00fcre\u00e7lerinde yer alacak Farmakogenetik testlerini ve poliklinikte yap\u0131lan \u00e7al\u0131\u015fmalar\u0131 anlatt\u0131. Her bireyin genetik bak\u0131mdan farkl\u0131 oldu\u011funu belirten Prof. Dr. Sa\u011flam, \u015f\u00f6yle konu\u015ftu: “Genetik farklar, bizi tek ve biricik bireyler haline getiriyor. Ancak t\u0131p, t\u00fcm insanlar\u0131 gruplara b\u00f6lerek tan\u0131ml\u0131yor. \u0130la\u00e7lar\u0131 kulland\u0131\u011f\u0131m\u0131zda da hastalar\u0131n y\u00fczde 70\u2019i standart tedaviye yan\u0131t veriyor. Geriye kalan y\u00fczde 30\u2019u ise ya yan\u0131t vermiyor ya da hastada yan etki ortaya \u00e7\u0131k\u0131yor. Baz\u0131 durumlarda her ikisi birden s\u00f6z konusu oluyor. Genetik biliminin ilerlemesi ve insan genomunun \u00e7\u00f6z\u00fclmesi; baz\u0131 insanlar\u0131n baz\u0131 ila\u00e7lara neden beklendi\u011fi gibi veya hi\u00e7 cevap vermedi\u011fini, baz\u0131lar\u0131nda ise neden yan etkilerin g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc ortaya \u00e7\u0131kard\u0131. Art\u0131k uygun ilac\u0131, uygun dozda ve uygun zamanda vererek hastan\u0131n ila\u00e7tan \u00fcst d\u00fczeyde faydalanmas\u0131n\u0131 ve yan etkinin de en alt d\u00fczeyde ortaya \u00e7\u0131kmas\u0131n\u0131 ama\u00e7l\u0131yoruz.”<\/p>\n
T\u0131pta b\u00fcy\u00fck d\u00f6n\u00fc\u015f\u00fcm<\/p>\n
Geleneksel t\u0131pta ilac\u0131n hekimin t\u0131p bilgisi ve tecr\u00fcbesine g\u00f6re hastaya verildi\u011fini anlatan Prof. Dr. Sa\u011flam, genetik testlerin ise hastaya en uygun ila\u00e7lar\u0131 ve dozu belirledi\u011fini s\u00f6yledi.<\/p>\n
Farmakogenetik \u00e7al\u0131\u015fmalar\u0131na D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc\u2019n\u00fcn de \u00f6ncelikli olarak \u00f6nem verdi\u011fini belirten Prof. Dr. Sa\u011flam, uygun olmayan ila\u00e7la tedavi edilmeye \u00e7al\u0131\u015f\u0131lmas\u0131 nedeniyle hastalar\u0131n s\u0131k s\u0131k hastaneye gitmesi, s\u00fcrekli tetkik yapt\u0131rmas\u0131 ve hastanede yatmas\u0131 gibi sonu\u00e7lar dikkate al\u0131nd\u0131\u011f\u0131nda farmakogenetik \u00e7al\u0131\u015fmalar\u0131n sa\u011fl\u0131k sisteminin t\u00fcm\u00fc i\u00e7in b\u00fcy\u00fck fayda getirece\u011fini belirtti.<\/p>\n
“Bundan sonra art\u0131k hastalar doktorlar\u0131na giderken genetik testlerini yanlar\u0131nda g\u00f6t\u00fcrecekler”<\/p>\n
Maltepe \u00dcniversitesi T\u0131p Fak\u00fcltesi Hastanesi\u2019nde a\u00e7\u0131lan Farmakogenetik Poliklini\u011fi\u2019nde hasta muayenesine ba\u015flad\u0131klar\u0131n\u0131 belirten Prof. Dr. Sa\u011flam, d\u00fcnyada daha yayg\u0131n olan farmakogenetik uygulamalar\u0131n\u0131n hen\u00fcz T\u00fcrkiye\u2019de rutin \u015fekilde yap\u0131lamad\u0131\u011f\u0131na da dikkat \u00e7ekti.<\/p>\n
Prof. Dr. Sa\u011flam, hizmet veren polikliniklerinde \u00f6ncelikli olarak \u00e7ocuklar, ya\u015fl\u0131lar, \u00e7oklu ila\u00e7 kullananlar, gebeler, emzirenler ile birlikte birden fazla te\u015fhis nedeniyle tedavi g\u00f6ren hastalara \u00f6ncelik verildi\u011fini s\u00f6yleyerek, “\u0130laca yan\u0131t vermeyen veya yan etki g\u00f6r\u00fclen hastalar\u0131n \u00f6nce genetik yap\u0131s\u0131n\u0131 anlamak i\u00e7in koldan kan, sa\u00e7 k\u00f6k\u00fc \u00f6rne\u011fi veya yanaktan s\u00fcr\u00fcnt\u00fc al\u0131narak genetik test yap\u0131yoruz. Genetik test, \u00f6m\u00fcr boyu ge\u00e7erli. Bundan sonra art\u0131k hastalar doktorlar\u0131na giderken genetik testlerini yanlar\u0131nda g\u00f6t\u00fcrecekler. Re\u00e7eteler ona g\u00f6re verilecek. Gelecekte bu testler do\u011fumdan hemen sonra yap\u0131lacak.” dedi.<\/p>\n
Yan etki tarihe kar\u0131\u015facak<\/p>\n
Testler sayesinde elde edilen sonu\u00e7larla yan etkilerin minimum d\u00fczeye inece\u011fini; hastal\u0131klar\u0131n ilerleyi\u015finin durdurulabilece\u011fini dile getiren Prof. Dr. Sa\u011flam, s\u00f6zlerini \u015f\u00f6yle tamamlad\u0131: “Do\u011fru ila\u00e7 tespiti ile birlikte birden fazla hastal\u0131\u011f\u0131 olup \u00e7ok say\u0131da ila\u00e7 kullananlar\u0131n, ila\u00e7lar\u0131n birbirleriyle olan etkile\u015fimleri nedeniyle ya\u015fad\u0131klar\u0131 sorunlar ortadan kalk\u0131yor. \u0130laca yan\u0131t vermeyen hastalarda bile b\u00fcy\u00fck ba\u015far\u0131 elde ediliyor. Asl\u0131nda hi\u00e7bir ilac\u0131n kullan\u0131lmas\u0131n\u0131n tercih edilmedi\u011fi gebelerde de zorunlu hallerde bebe\u011fe ve anneye hemen hi\u00e7 zarar vermeyecek ila\u00e7lar\u0131n se\u00e7ilmesini sa\u011fl\u0131yor. Emziren annelerde de ila\u00e7 miktar\u0131n\u0131n bebe\u011fe en az ge\u00e7ece\u011fi doz ve uygun doz d\u00fczenlemesi yap\u0131l\u0131yor. \u00c7ocuklar\u0131n tedavisi i\u00e7in de uygun ila\u00e7 ve dozun belirlenmesi m\u00fcmk\u00fcn hale geliyor.”<\/p>\n","protected":false},"excerpt":{"rendered":"
\u0130LA\u00c7 TEDAV\u0130S\u0130N\u0130N HASTALARIN GENET\u0130K YAPISINA G\u00d6RE ETK\u0130LER\u0130N\u0130 SAPTAYAN FARMAKOGENET\u0130K \u00c7ALI\u015eMALARININ \u00d6NEM\u0130 G\u00dcN GE\u00c7T\u0130K\u00c7E ARTTI\u011eI BEL\u0130RT\u0130L\u0130YOR. FARMAKOGENET\u0130K TESTLER; HANG\u0130 HASTANIN, HANG\u0130 \u0130LACI, HANG\u0130 DOZDA KULLANMASI GEREKT\u0130\u011e\u0130N\u0130 S\u00d6YL\u00dcYOR. BUNUN SONUCUNDA MALTEPE \u00dcN\u0130VERS\u0130TES\u0130 TIP FAK\u00dcLTES\u0130 TIBB\u0130 FARMAKOLOJ\u0130 ANAB\u0130L\u0130M DALI\u2019NA BA\u011eLI OLARAK TIP FAK\u00dcLTES\u0130 HASTANES\u0130NDE A\u00c7ILAN FARMAKOGENET\u0130K POL\u0130KL\u0130N\u0130\u011e\u0130, \u0130LA\u00c7LARIN ETK\u0130LER\u0130N\u0130 BEL\u0130RLEYEN FARMAKOGENET\u0130K TESTLER\u0130 UYGULAMAYA BA\u015eLADI\u011eINI A\u00c7IKLADI.<\/p>\n","protected":false},"author":1,"featured_media":253494,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[36936,62704,13855,192,31554,15659,5023],"class_list":["post-253493","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-etki","tag-farmakogenetik","tag-ilacta","tag-ile","tag-karisacak","tag-tarihe","tag-yan"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.tvturk.com\/wp-content\/uploads\/2020\/01\/farmakogenetik-ile-ilacta-yan-etki-tarihe-karisacak_f41544a.jpg?fit=1000%2C722","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paKIfm-13WB","_links":{"self":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/253493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/comments?post=253493"}],"version-history":[{"count":0,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/posts\/253493\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media\/253494"}],"wp:attachment":[{"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/media?parent=253493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/categories?post=253493"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.tvturk.com\/index.php\/wp-json\/wp\/v2\/tags?post=253493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}